MyBioSource.com's RAT ANTI MOUSE CD41:RPE is a Rat monoclonal antibody. The RAT ANTI MOUSE CD41:RPE Antibody was generated using CD41, CD41b, GpIIb, HPA3, integrin, alpha 2b, and ITGA2B as the antigen. It reacts with Mouse. This antibody has been shown to work in applications such as: Flow Cytometry.
Description
Rat anti Mouse CD41 antibody, clone MWReg30 recognizes the mouse integrin alpha IIb subunit CD41. CD41 is a ~125kDa single pass type 1 transmembrane glycoprotein expressed by platelets, megakaryocytes (Zhang et al. 2007), mast cells (Berlanga et al. 2005)and hematopoietic progenitors (Mitjavila-Garcia et al. 2002). CD41 forms a heterodimer with CD61. The CD41/CD61 complex is important for platelet adhesion and aggregation (Patel et al. 2003) acting as a receptor for many extracellular matrix proteins including fibronectin, thrombospondin and vitronectin (Weisel et al. 1992). Rat anti mouse CD41, clone MWReg30 has been reported to inhibit PMA induced aggregation in vitro and to induce hypothermia in vivo (Nieswandt et al. 1999)